Automake has support for an obscure feature called multilibs. A multilib is a library which is built for multiple different ABIs at a single time; each time the library is built with a different target flag combination. This is only useful when the library is intended to be cross-compiled, and it is almost exclusively used for compiler support libraries.
The multilib support is still experimental. Only use it if you are familiar with multilibs and can debug problems you might encounter.